A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1

Pat Bailey

doi:10.1039/c5md00575b

A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1

Pat Bailey

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

© The Royal Society of Chemistry 2016.The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.

Original language	English
Pages (from-to)	999 - 1002
Journal	MedChemComm
DOIs	https://doi.org/10.1039/c5md00575b
Publication status	Published - 15 Mar 2016
Externally published	Yes

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10.1039/c5md00575bLicence: CC BY-NC-ND 4.0

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title = "A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1",

abstract = "{\textcopyright} The Royal Society of Chemistry 2016.The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.",

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AB - © The Royal Society of Chemistry 2016.The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.

U2 - 10.1039/c5md00575b

DO - 10.1039/c5md00575b

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A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1

Abstract

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