An integrative model of perseverative thinking

Lorenzo Mattioni, Ana V. Nikčević, Francesca Ferri, Marcantonio M. Spada, Carlo Sestieri

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Abstract

People spend most of their waking hours detached from external stimuli, remembering the past, foreseeing the future, imagining situations in which they did not attend or that have never existed, or, simply, thinking. Such a process is crucial for mental health. A common feature of many mental disorders is recurrent stress-related thoughts, the so-called ‘perseverative thinking’. In this review, we describe how perseverative thinking represents a dysfunctional self-regulatory strategy that maintains and increases the effects of mental suffering and arises from the maladaptive interplay between discrepancy monitoring, strategy selection, executive regulation, and information representation. We further argue that perseverative thinking can change how the mind represents the world through memory updating, resulting in an increased perceived need for regulation of the external and internal inputs. Lastly, we propose a new integrated model incorporating the different features of perseverative thinking, offering a more unified perspective on psychopathology.

Original languageEnglish
Pages (from-to)34-54
Number of pages21
JournalDialogues in Clinical Neuroscience
Volume27
Issue number1
DOIs
Publication statusPublished - 23 May 2025

Bibliographical note

Publisher Copyright:
© 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • allostasis
  • executive functions
  • memory reconsolidation
  • perseverative thinking
  • self-regulation

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