Induction of leukaemia in chloramphenicol-treated toads

M. M. El-Mofty; N. E. Abdelmeguid; I. A. Sadek; A. E. Essawy; E. A. Abdel Aleem

doi:10.26719/2000.6.5-6.1026

Induction of leukaemia in chloramphenicol-treated toads

M. M. El-Mofty, N. E. Abdelmeguid, I. A. Sadek, A. E. Essawy, E. A. Abdel Aleem

Alexandria University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Chloramphenicol has been associated with the development of aplastic anaemia. As it is still widely used in Egypt, we studied its effect on 100 Egyptian toads (Bufo regularis) given a dose of chloramphenlcol of 5 mg/40 g body weight for 12 weeks. We found it induced numerous, severe ultrastructural changes in almost all types of leukocytes. These changes were similar to those induced by the chemical carcinogen 7,12-dimethylbenz(a)anthracene in 100 toads used as the carcinogen control group, and similar to those in leukocytes reported in humans with leukaemia. We recommend regulations be applied on the use of this antibiotic in countries where it is still widely used.

Original language	English
Pages (from-to)	1026-1034
Number of pages	9
Journal	Eastern Mediterranean Health Journal
Volume	6
Issue number	5-6
DOIs	https://doi.org/10.26719/2000.6.5-6.1026
Publication status	Published - 2000
Externally published	Yes

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title = "Induction of leukaemia in chloramphenicol-treated toads",

abstract = "Chloramphenicol has been associated with the development of aplastic anaemia. As it is still widely used in Egypt, we studied its effect on 100 Egyptian toads (Bufo regularis) given a dose of chloramphenlcol of 5 mg/40 g body weight for 12 weeks. We found it induced numerous, severe ultrastructural changes in almost all types of leukocytes. These changes were similar to those induced by the chemical carcinogen 7,12-dimethylbenz(a)anthracene in 100 toads used as the carcinogen control group, and similar to those in leukocytes reported in humans with leukaemia. We recommend regulations be applied on the use of this antibiotic in countries where it is still widely used.",

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AU - Sadek, I. A.

AU - Essawy, A. E.

AU - Abdel Aleem, E. A.

PY - 2000

Y1 - 2000

N2 - Chloramphenicol has been associated with the development of aplastic anaemia. As it is still widely used in Egypt, we studied its effect on 100 Egyptian toads (Bufo regularis) given a dose of chloramphenlcol of 5 mg/40 g body weight for 12 weeks. We found it induced numerous, severe ultrastructural changes in almost all types of leukocytes. These changes were similar to those induced by the chemical carcinogen 7,12-dimethylbenz(a)anthracene in 100 toads used as the carcinogen control group, and similar to those in leukocytes reported in humans with leukaemia. We recommend regulations be applied on the use of this antibiotic in countries where it is still widely used.

AB - Chloramphenicol has been associated with the development of aplastic anaemia. As it is still widely used in Egypt, we studied its effect on 100 Egyptian toads (Bufo regularis) given a dose of chloramphenlcol of 5 mg/40 g body weight for 12 weeks. We found it induced numerous, severe ultrastructural changes in almost all types of leukocytes. These changes were similar to those induced by the chemical carcinogen 7,12-dimethylbenz(a)anthracene in 100 toads used as the carcinogen control group, and similar to those in leukocytes reported in humans with leukaemia. We recommend regulations be applied on the use of this antibiotic in countries where it is still widely used.

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SP - 1026

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JO - Eastern Mediterranean Health Journal

JF - Eastern Mediterranean Health Journal

IS - 5-6

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Induction of leukaemia in chloramphenicol-treated toads

Abstract

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