Abstract
© 2016 Elsevier Inc. All rights reserved. This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins, including the liver-secreted systemic iron-regulator hepcidin. Downregulation of hepcidin is the key reason for increased duodenal iron absorption, which causes high circulating and stored iron levels in alcoholics, similar to that attained in hereditary hemochromatosis. The resultant free-iron mediated cytotoxicity is a common determinant of the pathophysiology of cirrhosis, an advanced liver condition observed in both alcoholic liver disease (ALD), and congenital hemochromatosis. Often, alcohol consumption suppresses hematopoiesis and/or hinders normal erythrocyte maturation, which results in anemia. Due to these alcohol-induced changes in iron metabolism, several iron-related biomarkers, like serum levels of ferritin and the glycosylation status of transferrin, are used to detect ALD. Also, modulation of hepcidin expression has been explored as a therapy to limit duodenal iron absorption and thereby restrain the tissue injury mediated by excess iron.
Original language | English |
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Title of host publication | Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series |
Publisher | Academic Press |
Number of pages | 14 |
Edition | 1 |
DOIs | |
Publication status | Published - 1 Jan 2016 |
Externally published | Yes |