PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques

Joseph Lillington; Ludovica Brusaferri; Kerstin Kläser; Karin Shmueli; Radhouene Neji; Brian F. Hutton; Francesco Fraioli; Simon Arridge; Manuel Jorge Cardoso; Sebastien Ourselin; Kris Thielemans; David Atkinson

doi:10.1002/mp.13943

PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques

Joseph Lillington, Ludovica Brusaferri, Kerstin Kläser, Karin Shmueli, Radhouene Neji, Brian F. Hutton, Francesco Fraioli, Simon Arridge, Manuel Jorge Cardoso, Sebastien Ourselin, Kris Thielemans, David Atkinson

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

Positron emission tomography/magnetic resonance imaging (PET/MRI) potentially offers several advantages over positron emission tomography/computed tomography (PET/CT), for example, no CT radiation dose and soft tissue images from MR acquired at the same time as the PET. However, obtaining accurate linear attenuation correction (LAC) factors for the lung remains difficult in PET/MRI. LACs depend on electron density and in the lung, these vary significantly both within an individual and from person to person. Current commercial practice is to use a single-valued population-based lung LAC, and better estimation is needed to improve quantification. Given the under-appreciation of lung attenuation estimation as an issue, the inaccuracy of PET quantification due to the use of single-valued lung LACs, the unique challenges of lung estimation, and the emerging status of PET/MRI scanners in lung disease, a review is timely. This paper highlights past and present methods, categorizing them into segmentation, atlas/mapping, and emission-based schemes. Potential strategies for future developments are also presented.

Original language	English
Pages (from-to)	790-811
Number of pages	22
Journal	Medical Physics
Volume	47
Issue number	2
DOIs	https://doi.org/10.1002/mp.13943 https://doi.org/10.1002/mp.13943
Publication status	Published - 3 Dec 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Keywords

attenuation estimation
lung
magnetic resonance imaging
medical imaging
positron emission tomography

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10.1002/mp.13943
10.1002/mp.13943Licence: CC BY 4.0

Cite this

Lillington, J., Brusaferri, L., Kläser, K., Shmueli, K., Neji, R., Hutton, B. F., Fraioli, F., Arridge, S., Cardoso, M. J., Ourselin, S., Thielemans, K., & Atkinson, D. (2019). PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques. Medical Physics, 47(2), 790-811. https://doi.org/10.1002/mp.13943, https://doi.org/10.1002/mp.13943

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title = "PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques",

abstract = "Positron emission tomography/magnetic resonance imaging (PET/MRI) potentially offers several advantages over positron emission tomography/computed tomography (PET/CT), for example, no CT radiation dose and soft tissue images from MR acquired at the same time as the PET. However, obtaining accurate linear attenuation correction (LAC) factors for the lung remains difficult in PET/MRI. LACs depend on electron density and in the lung, these vary significantly both within an individual and from person to person. Current commercial practice is to use a single-valued population-based lung LAC, and better estimation is needed to improve quantification. Given the under-appreciation of lung attenuation estimation as an issue, the inaccuracy of PET quantification due to the use of single-valued lung LACs, the unique challenges of lung estimation, and the emerging status of PET/MRI scanners in lung disease, a review is timely. This paper highlights past and present methods, categorizing them into segmentation, atlas/mapping, and emission-based schemes. Potential strategies for future developments are also presented.",

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doi = "10.1002/mp.13943",

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Lillington, J, Brusaferri, L, Kläser, K, Shmueli, K, Neji, R, Hutton, BF, Fraioli, F, Arridge, S, Cardoso, MJ, Ourselin, S, Thielemans, K & Atkinson, D 2019, 'PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques', Medical Physics, vol. 47, no. 2, pp. 790-811. https://doi.org/10.1002/mp.13943, https://doi.org/10.1002/mp.13943

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T2 - A review of past, present, and potential techniques

AU - Lillington, Joseph

AU - Brusaferri, Ludovica

AU - Kläser, Kerstin

AU - Shmueli, Karin

AU - Neji, Radhouene

AU - Hutton, Brian F.

AU - Fraioli, Francesco

AU - Arridge, Simon

AU - Cardoso, Manuel Jorge

AU - Ourselin, Sebastien

AU - Thielemans, Kris

AU - Atkinson, David

PY - 2019/12/3

Y1 - 2019/12/3

N2 - Positron emission tomography/magnetic resonance imaging (PET/MRI) potentially offers several advantages over positron emission tomography/computed tomography (PET/CT), for example, no CT radiation dose and soft tissue images from MR acquired at the same time as the PET. However, obtaining accurate linear attenuation correction (LAC) factors for the lung remains difficult in PET/MRI. LACs depend on electron density and in the lung, these vary significantly both within an individual and from person to person. Current commercial practice is to use a single-valued population-based lung LAC, and better estimation is needed to improve quantification. Given the under-appreciation of lung attenuation estimation as an issue, the inaccuracy of PET quantification due to the use of single-valued lung LACs, the unique challenges of lung estimation, and the emerging status of PET/MRI scanners in lung disease, a review is timely. This paper highlights past and present methods, categorizing them into segmentation, atlas/mapping, and emission-based schemes. Potential strategies for future developments are also presented.

AB - Positron emission tomography/magnetic resonance imaging (PET/MRI) potentially offers several advantages over positron emission tomography/computed tomography (PET/CT), for example, no CT radiation dose and soft tissue images from MR acquired at the same time as the PET. However, obtaining accurate linear attenuation correction (LAC) factors for the lung remains difficult in PET/MRI. LACs depend on electron density and in the lung, these vary significantly both within an individual and from person to person. Current commercial practice is to use a single-valued population-based lung LAC, and better estimation is needed to improve quantification. Given the under-appreciation of lung attenuation estimation as an issue, the inaccuracy of PET quantification due to the use of single-valued lung LACs, the unique challenges of lung estimation, and the emerging status of PET/MRI scanners in lung disease, a review is timely. This paper highlights past and present methods, categorizing them into segmentation, atlas/mapping, and emission-based schemes. Potential strategies for future developments are also presented.

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KW - magnetic resonance imaging

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PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques

Abstract

Bibliographical note

Keywords

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