Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs

Keyphrases

• System Level 100%
• In Cancer 100%
• Cancer Cells 100%
• Druggability 100%
• Induced Stress 100%
• Chemotherapy-induced 100%
• Proteasome Inhibition 66%
• General Controls 66%
• Vulnerability 33%
• Cancer Therapy 33%
• Amino Acids 33%
• New Drug Targets 33%
• Tumor Cells 33%
• Bona Fide 33%
• Transcriptome Analysis 33%
• Dynamic Change 33%
• Solid Cancer 33%
• Metabolomics 33%
• Myeloma Cells 33%
• Cellular Response 33%
• Global Mechanism 33%
• Omics Approaches 33%
• Key Recovery 33%
• Stressed Cells 33%
• Molecular Characteristics 33%
• Proteome 33%
• Therapeutic Routes 33%
• Cellular Recovery 33%
• Mitochondrial Function 33%
• Analysis pipeline 33%
• Proteotoxic Stress 33%
• Lipid Suppression 33%
• Glucose Metabolism 33%
• Lipid Metabolism 33%
• Therapy Optimization 33%
• Insults 33%
• Transcriptome 33%
• Transcriptional Signature 33%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Proteasome 100%
• Amino Acids 50%
• Gene Expression Profiling 50%
• Glucose Metabolism 50%
• Proteome 50%
• Transcriptome 50%
• Lipid Metabolism 50%
• Metabolome 50%