The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man

M. M. El-Mofty; N. E. Abdel-Meguid; I. A. Sadek; A. E. Essawy; E. A. Abdel-Aleem

doi:10.3892/or.4.3.657

The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man

M. M. El-Mofty
, N. E. Abdel-Meguid
, I. A. Sadek
, A. E. Essawy
, E. A. Abdel-Aleem

Alexandria University
Department of Zoology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Injection of Egyptian toads Bufo regularis, with adriamycin subcutaneously in the dorsal lymph sac at a dose level of 0.1 mg/toad, once every 3 weeks for 3 months induced pronounced alterations in the blood cells. These alterations were more or less similar to the criteria reported in human leukaemia. These changes were all comparable to those observed after the treatment of the experimental animals with the chemical carcinogen 7,12-dimethylbenz(a)anthracene. It is speculated that toads (Bufo regularis) can be used as biological test animals for screening chemicals or drugs which induce leukaemia in man.

Original language	English
Pages (from-to)	657-660
Number of pages	4
Journal	Oncology Reports
Volume	4
Issue number	3
DOIs	https://doi.org/10.3892/or.4.3.657
Publication status	Published - 1997
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

7,12-dimethylbenz(a)anthracine
adriamycin
Bufo regularis
leukaemia

Access to Document

10.3892/or.4.3.657

Cite this

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title = "The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man",

abstract = "Injection of Egyptian toads Bufo regularis, with adriamycin subcutaneously in the dorsal lymph sac at a dose level of 0.1 mg/toad, once every 3 weeks for 3 months induced pronounced alterations in the blood cells. These alterations were more or less similar to the criteria reported in human leukaemia. These changes were all comparable to those observed after the treatment of the experimental animals with the chemical carcinogen 7,12-dimethylbenz(a)anthracene. It is speculated that toads (Bufo regularis) can be used as biological test animals for screening chemicals or drugs which induce leukaemia in man.",

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author = "El-Mofty, \{M. M.\} and Abdel-Meguid, \{N. E.\} and Sadek, \{I. A.\} and Essawy, \{A. E.\} and Abdel-Aleem, \{E. A.\}",

year = "1997",

doi = "10.3892/or.4.3.657",

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T1 - The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man

AU - El-Mofty, M. M.

AU - Abdel-Meguid, N. E.

AU - Sadek, I. A.

AU - Essawy, A. E.

AU - Abdel-Aleem, E. A.

PY - 1997

Y1 - 1997

N2 - Injection of Egyptian toads Bufo regularis, with adriamycin subcutaneously in the dorsal lymph sac at a dose level of 0.1 mg/toad, once every 3 weeks for 3 months induced pronounced alterations in the blood cells. These alterations were more or less similar to the criteria reported in human leukaemia. These changes were all comparable to those observed after the treatment of the experimental animals with the chemical carcinogen 7,12-dimethylbenz(a)anthracene. It is speculated that toads (Bufo regularis) can be used as biological test animals for screening chemicals or drugs which induce leukaemia in man.

AB - Injection of Egyptian toads Bufo regularis, with adriamycin subcutaneously in the dorsal lymph sac at a dose level of 0.1 mg/toad, once every 3 weeks for 3 months induced pronounced alterations in the blood cells. These alterations were more or less similar to the criteria reported in human leukaemia. These changes were all comparable to those observed after the treatment of the experimental animals with the chemical carcinogen 7,12-dimethylbenz(a)anthracene. It is speculated that toads (Bufo regularis) can be used as biological test animals for screening chemicals or drugs which induce leukaemia in man.

KW - 7,12-dimethylbenz(a)anthracine

KW - adriamycin

KW - Bufo regularis

KW - leukaemia

UR - https://www.scopus.com/pages/publications/0030954082

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DO - 10.3892/or.4.3.657

M3 - Article

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SN - 1021-335X

VL - 4

SP - 657

EP - 660

JO - Oncology Reports

JF - Oncology Reports

IS - 3

ER -

The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man

Abstract

UN SDGs

Keywords

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