Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells.

Afnan H. El‐gowily, Samah A. Loutfy, Ehab M.M. Ali, Tarek M. Mohamed, Mohammed A. Mansour

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The journal retracts the article titled “Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells.” [1], cited above.
Following the article’s publication, concerns were brought to the attention of the Editorial Office regarding the reliability of the figures presented in this article [1].
Adhering to our complaints procedure, the investigation was conducted by the Editorial Office and Editorial Board. During this process, the authors were unable to satisfactorily explain the similarities between Figure 4(I-A) and Supplementary Figure S5(C II), nor could they provide the raw materials for the Editorial Board evaluation. As a result, the Editorial Board has lost confidence in the reliability of the findings and decided to retract this publication [1], as per MDPI’s retraction policy (https://www.mdpi.com/ethics#_bookmark30, accessed on 6 January 2025).
This retraction was approved by the Editor-in-Chief of Pharmaceuticals.
The authors disagree with this decision.
Original languageEnglish
Article number254
JournalPharmaceuticals
Volume14
Issue number3
DOIs
Publication statusPublished - 11 Mar 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Apoptosis
  • Autophagy
  • Chloroquine
  • Doxorubicin
  • PI3K
  • Tioconazole

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